Reticulocytopenic, Coombs’ Positive Anemia Induced by Procainamide

Anemia with positive direct Coombs' test induced by trypan blue.

as evidence of autoimmune phenomena. The experimental production of positive antiglobulin tests by drugs and chemical agents, however, has suggested that nonimmunologic mechanisms may also be responsible for protein coating of erythrocytes.2’3 During attempts to produce tumors of the reticuloendothelial system in rats by injection of trypan blue, an anemia, chacacterized by increased ervthrocyt...

Positive direct Coombs test induced by phenylhydrazine.

Severe bone marrow aplasia and Coombs-positive autoimmune hemolytic anemia in microfilariasis - coincidental or causal?

Address for Correspondence: Upendra Mogalluru Srinivas, Department of Hematology, Global Hospitals, Lakdi-ka-Pul, 500004, Hyderabad, India Phone: +91 9440837561 E-mail: [email protected] A 28-year-old male presented with generalized weakness, fever, high colored urine and severe anemia, icterus and petechiae. His hemoglobin (Hb) and total leukocyte, platelet and absolute reticulocyte...

Direct antiglobulin ("Coombs") test-negative autoimmune hemolytic anemia: a review.

We have reviewed the literature to identify and characterize reports of warm-antibody type, autoimmune hemolytic anemia in which the standard direct antiglobulin reaction was negative but a confirmatory test indicated that the red cells were opsonized with antibody. Three principal reasons account for the absence of a positive direct antiglobulin test in these cases: a) IgG sensitization below ...

Coombs-Negative Autoimmune Hemolytic Anemia in Crohn’s Disease

BACKGROUND Anemia is a common, important extraintestinal complication of Crohn's disease. The main types of anemia in patients with Crohn's disease are iron deficiency anemia and anemia of chronic disease. Although patients with Crohn's disease may experience various type of anemia, autoimmune hemolytic anemia (AIHA) in patients with Crohn's disease, especially Coombs-negative AIHA, is very rar...